Neutrophil extracellular traps: from physiology to pathology

A Hidalgo, P Libby, O Soehnlein… - Cardiovascular …, 2022 - academic.oup.com
At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease

V Poli, I Zanoni - Trends in microbiology, 2023 - cell.com
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

[HTML][HTML] The pathology of asthma: what is obstructing our view?

H Aegerter, BN Lambrecht - Annual Review of Pathology …, 2023 - annualreviews.org
Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

Combating implant infections: shifting focus from bacteria to host

S Amin Yavari, SM Castenmiller… - Advanced …, 2020 - Wiley Online Library
The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

Control of innate immune response by biomaterial surface topography, energy, and stiffness

JO Abaricia, N Farzad, TJ Heath, J Simmons… - Acta Biomaterialia, 2021 - Elsevier
As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

J Dong, W Wang, W Zhou, S Zhang, M Li, N Li… - Biomaterials …, 2022 - spj.science.org
Implant-associated infection (IAI) is increasingly emerging as a serious threat with the
massive application of biomaterials. Bacteria attached to the surface of implants are often …

[HTML][HTML] Neutrophil extracellular traps tied to rheumatoid arthritis: points to ponder

W Song, J Ye, N Pan, C Tan, M Herrmann - Frontiers in Immunology, 2021 - frontiersin.org
In recent years, neutrophil extracellular traps at the forefront of neutrophil biology have
proven to help capture and kill pathogens involved in the inflammatory process. There is …

Substrate stiffness induces neutrophil extracellular trap (NET) formation through focal adhesion kinase activation

JO Abaricia, AH Shah, R Olivares-Navarrete - Biomaterials, 2021 - Elsevier
Neutrophils predominate the early inflammatory response to tissue injury and implantation of
biomaterials. Recent studies have shown that neutrophil activation can be regulated by …

[HTML][HTML] Antibacterial designs for implantable medical devices: Evolutions and challenges

H Cao, S Qiao, H Qin, KD Jandt - Journal of Functional Biomaterials, 2022 - mdpi.com
The uses of implantable medical devices are safer and more common since sterilization
methods and techniques were established a century ago; however, device-associated …

[HTML][HTML] Dysregulated neutrophil phenotype and function in hospitalised non-ICU COVID-19 pneumonia

KBR Belchamber, OS Thein, J Hazeldine… - Cells, 2022 - mdpi.com
Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts.
Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single …