Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …

In the long history of traditional Chinese medicine, single herbs and complex formulas have
been suggested to increase lifespan. However, the identification of single molecules …

In a first step of DNA double-strand break (DSB) repair by homologous recombination, DNA
ends are resected such that single-stranded DNA (ssDNA) overhangs are generated …

Aging has become one of the fastest-growing research topics in biology. However, exactly
how the aging process occurs remains unknown. Epigenetics plays a significant role, and …

Genome instability is a hallmark of aging and contributes to age-related disorders such as
cancer and Alzheimer's disease. The accumulation of DNA damage during aging has been …

Genome instability is a hallmark of aging, with the highly repetitive ribosomal DNA (rDNA)
within the nucleolus being particularly prone to genome instability. Nucleolar enlargement …

Quiescence or G0 is a reversible state in which cells cease division but retain the ability to
resume proliferation. Quiescence occurs in all organisms and is essential for stem cell …

Mono-methylation of the fourth lysine on the N-terminal tail of histone H3 was found to
support the induction of RNA polymerase II transcription in S. cerevisiae during nutrient …

As the global population experiences a notable surge in aging demographics, the need to
understand the intricate molecular pathways exacerbated by age-related stresses, including …