Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although
most often well tolerated, severe toxicity is encountered in~ 20–30% of the patients …

5‐Fluorouracil (5‐FU) is dosed by body surface area, a practice unable to reduce the
interindividual variability in exposure. Endorsed by the International Association of …

Simple Summary 5-Fluorouracil (5-FU) is a chemotherapy drug that is commonly used to
treat multiple cancers. Many people who are treated with 5-FU experience severe toxicity to …

5-Fluorouracil (5-FU) and its prodrug capecitabine are key chemotherapeutic agents in the
treatment of many gastrointestinal tract adenocarcinomas. In addition to their beneficial …

Fluoropyrimidines remain the cornerstone of treatment for different types of cancer, and are
used by an estimated two million patients annually. The toxicity associated with …

ABSTRACT Introduction Adverse drug reactions (ADRs) are among the leading causes of
death, and frequently associated with drug–gene interactions (DGIs). In addition to …

Objective: Our objective is to document progress in developing personalized therapy with
fluoropyrimidine drugs (FPs) to improve outcomes for cancer patients and to identify areas …

Objective The aim of this study was to evaluate the use of plasma and saliva uracil (U) to
dihydrouracil (UH 2) metabolic ratio and DPYD genotyping, as a means to identify patients …

We searched PubMed entries and the Lattes database of Brazilian Pharmacogenetics
Network investigators, for pharmacogenetic/genomic (PGx) studies in the Brazilian …

Fluoropyrimidines, after more than 50 years from their discovery, are still the treatment of
many types of cancer, and it is estimated that two million patients receive fluoropyrimidine …