Relevance of peroxisome proliferator activated receptors in multitarget paradigm associated with the endocannabinoid system
A Lago-Fernandez, S Zarzo-Arias, N Jagerovic… - International Journal of …, 2021 - mdpi.com
Cannabinoids have shown to exert their therapeutic actions through a variety of targets.
These include not only the canonical cannabinoid receptors CB1R and CB2R but also …
These include not only the canonical cannabinoid receptors CB1R and CB2R but also …
Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform
M Zeghal, G Laroche, JD Freitas, R Wang… - Nature …, 2023 - nature.com
Representing the most attractive and successful druggable receptors of the proteome,
GPCRs regulate a myriad of physiological and pathophysiological functions. Although over …
GPCRs regulate a myriad of physiological and pathophysiological functions. Although over …
Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review
LM Rodríguez-Serrano… - International Journal of …, 2023 - mdpi.com
The CB2 cannabinoid receptor has been found in brain areas that are part of the reward
system and has been shown to play a role in food intake regulation. Herein, we conducted a …
system and has been shown to play a role in food intake regulation. Herein, we conducted a …
Platform reagents enable synthesis of ligand-directed covalent probes: study of cannabinoid receptor 2 in live cells
Pharmacological modulation of cannabinoid receptor type 2 (CB2R) holds promise for the
treatment of neuroinflammatory disorders, such as Alzheimer's disease. Despite the …
treatment of neuroinflammatory disorders, such as Alzheimer's disease. Despite the …
Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor
G Turu, E Soltész-Katona, AD Tóth, C Juhász… - Frontiers in …, 2021 - frontiersin.org
β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their
intracellular trafficking and signaling. Development of biased GPCR agonists, selectively …
intracellular trafficking and signaling. Development of biased GPCR agonists, selectively …
Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity
AB Mahardhika, M Załuski, CT Schoeder… - Journal of Medicinal …, 2024 - ACS Publications
The human orphan G protein-coupled receptor GPR18, activated by Δ9-
tetrahydrocannabinol (THC), constitutes a promising drug target in immunology and cancer …
tetrahydrocannabinol (THC), constitutes a promising drug target in immunology and cancer …