The stiffness of living tissues and its implications for tissue engineering

CF Guimarães, L Gasperini, AP Marques… - Nature Reviews …, 2020 - nature.com
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

[HTML][HTML] Cells, materials, and fabrication processes for cardiac tissue engineering

P Montero, M Flandes-Iparraguirre… - … in Bioengineering and …, 2020 - frontiersin.org
Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …

In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid

ME Kupfer, WH Lin, V Ravikumar, K Qiu… - Circulation …, 2020 - Am Heart Assoc
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …

[HTML][HTML] 3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform

A Krakos, A Cieślak, E Hartel, MB Łabowska… - Microchimica Acta, 2023 - Springer
The results of a lab-on-chip (LOC) platform fabrication equipped with a hydrogel matrix is
reported. A 3D printing technique was used to provide a hybrid,“sandwiched” type structure …

[HTML][HTML] Engineering bio-inks for 3D bioprinting cell mechanical microenvironment

Y Yang, Y Jia, Q Yang, F Xu - International Journal of Bioprinting, 2023 - ncbi.nlm.nih.gov
Abstract 144Three-dimensional (3D) bioprinting has become a promising approach to
constructing functional biomimetic tissues for tissue engineering and regenerative medicine …

Materials for implantable surface electrode arrays: current status and future directions

CM Tringides, DJ Mooney - Advanced Materials, 2022 - Wiley Online Library
Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely
manipulated ductile metal films, which offer limited stretchability. However, the living tissues …

Substrate Stiffness and Particle Properties Influence Cellular Uptake of Nanoparticles and Viruses from the Ventral Side

JL Voigt, J Timmer, F Pennarola… - Advanced Functional …, 2023 - Wiley Online Library
It is a long‐standing challenge to exploit cellular uptake mechanisms to deliver desired
cargo into cells, for example, specific drugs or gene editing techniques. This study …

Fiber scaffold patterning for mending hearts: 3D organization bringing the next step

M Kristen, MJ Ainsworth, N Chirico… - Advanced …, 2020 - Wiley Online Library
Heart failure (HF) is a leading cause of death worldwide. The most common conditions that
lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood …

[HTML][HTML] 3D models of dilated cardiomyopathy: Shaping the chemical, physical and topographical properties of biomaterials to mimic the cardiac extracellular matrix

M Camman, P Joanne, O Agbulut, C Hélary - Bioactive Materials, 2022 - Elsevier
The pathophysiology of dilated cardiomyopathy (DCM), one major cause of heart failure, is
characterized by the dilation of the heart but remains poorly understood because of the lack …

3D printing of mechanically resistant poly (glycerol sebacate)(PGS)‐Zein scaffolds for potential cardiac tissue engineering applications

F Ruther, JA Roether… - Advanced Engineering …, 2022 - Wiley Online Library
Due to the limited regenerative capacity of the natural human myocardium, 3D printing of the
cyclic polyester poly (glycerol sebacate)(PGS) offers a promising alternative to produce …