Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Copper is an essential trace metal that is required for the catalysis of several important
cellular enzymes. However, since an excess of copper can also harm cells due to its …

The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally ever-growing.
Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of …

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in
numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

It is not often realized that the absolute protein specificity is an exception rather than a rule.
Two major kinds of protein multi-specificities are promiscuity and moonlighting. This review …

Copper is a transition metal that has been linked to pathological and beneficial effects in
neurodegenerative diseases. In Parkinson's disease, free copper is related to increased …

Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …