Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics
Protoporphyrin IX (PPIX) is an intermediate in the heme biosynthesis pathway. Abnormal
accumulation of PPIX due to certain pathological conditions such as erythropoietic …
accumulation of PPIX due to certain pathological conditions such as erythropoietic …
DeepP450: Predicting Human P450 Activities of Small Molecules by Integrating Pretrained Protein Language Model and Molecular Representation
J Chang, X Fan, B Tian - Journal of Chemical Information and …, 2024 - ACS Publications
Cytochrome P450 enzymes (CYPs) play a crucial role in Phase I drug metabolism in the
human body, and CYP activity toward compounds can significantly affect druggability …
human body, and CYP activity toward compounds can significantly affect druggability …
Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety
AS Surur, CF Chan, FM Bartz, ILK Wong… - RSC Medicinal …, 2024 - pubs.rsc.org
The lack of adequate anti-leishmanial therapies has led to the continued suffering of millions
of people from developing nations. Moreover, optimism for a therapeutic intervention by …
of people from developing nations. Moreover, optimism for a therapeutic intervention by …
[HTML][HTML] An unusual evolution of thyroid function after therapeutic plasma exchange in Graves' disease with cholestatic jaundice: A case report
Y Jin, X Feng, H Ni - Medicine, 2024 - journals.lww.com
Interventions: Methimazole was discontinued and the patient received 3 times of TPE, about
3-month glucocorticoid treatment, insulin administration accordingly and other conventional …
3-month glucocorticoid treatment, insulin administration accordingly and other conventional …
[HTML][HTML] Antithyroid Drug-Induced Hepatotoxicity From Chronic Methimazole Consumption Requiring Total Thyroidectomy
A Pekmezian, W Cobb, J Portoghese - Journal of Endocrine Surgery, 2024 - jes-online.org
Antithyroid drug-induced hepatotoxicity is extremely rare with very few reported cases in the
literature. The typical presentation of antithyroid drug-induced hepatotoxicity is acute onset …
literature. The typical presentation of antithyroid drug-induced hepatotoxicity is acute onset …