Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their
metabolic pathways. Mitochondria are important organelles for the metabolic …

Mitochondria play a key role in cancer and their involvement is not limited to the production
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …

Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates
disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) …

Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron
transport. A recently synthesized mitochondria‐targeted atovaquone increased …

Therapeutic targeting of tumor vulnerabilities is emerging as a key area of research. This
review is focused on exploiting the vulnerabilities of tumor cells and the immune cells in the …

Glycolytic and mitochondrial oxidative metabolism, which are two major energy sources in
tumors, are potential targets in cancer treatment. Metabolic reprogramming from glycolysis to …