Pleiotropy, epistasis and the genetic architecture of quantitative traits

TFC Mackay, RRH Anholt - Nature Reviews Genetics, 2024 - nature.com
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …

Epistasis and pleiotropy‐induced variation for plant breeding

SL Dwivedi, P Heslop‐Harrison, J Amas… - Plant Biotechnology …, 2024 - Wiley Online Library
Epistasis refers to nonallelic interaction between genes that cause bias in estimates of
genetic parameters for a phenotype with interactions of two or more genes affecting the …

[HTML][HTML] Genomic prediction using information across years with epistatic models and dimension reduction via haplotype blocks

E Vojgani, AC Hölker, M Mayer, CC Schön… - PLoS one, 2023 - journals.plos.org
The importance of accurate genomic prediction of phenotypes in plant breeding is
undeniable, as higher prediction accuracy can increase selection responses. In this regard …

Salinity stress tolerance prediction for biomass‐related traits in maize (Zea mays L.) using genome‐wide markers

V Singh, M Krause, D Sandhu, RS Sekhon… - The Plant …, 2023 - Wiley Online Library
Maize (Zea mays L.) is the third most important cereal crop after rice (Oryza sativa) and
wheat (Triticum aestivum). Salinity stress significantly affects vegetative biomass and grain …

[HTML][HTML] Investigating the impact of non-additive genetic effects in the estimation of variance components and genomic predictions for heat tolerance and performance …

LF de Oliveira, LF Brito, DBD Marques, DA da Silva… - BMC Genomic …, 2023 - Springer
Background Non-additive genetic effects are often ignored in livestock genetic evaluations.
However, fitting them in the models could improve the accuracy of genomic breeding values …

[HTML][HTML] Genomic prediction within and across maize landrace derived populations using haplotypes

YC Lin, M Mayer, D Valle Torres, T Pook… - Frontiers in Plant …, 2024 - frontiersin.org
Genomic prediction (GP) using haplotypes is considered advantageous compared to GP
solely reliant on single nucleotide polymorphisms (SNPs), owing to haplotypes' enhanced …

[HTML][HTML] Choosing the right tool: Leveraging of plant genetic resources in wheat (Triticum aestivum L.) benefits from selection of a suitable genomic prediction model

MO Berkner, AW Schulthess, Y Zhao, Y Jiang… - Theoretical and Applied …, 2022 - Springer
Key message Genomic prediction of genebank accessions benefits from the consideration
of additive-by-additive epistasis and subpopulation-specific marker effects. Abstract Wheat …

[PDF][PDF] Accelerating single-step evaluations through GPU offloading

A Freudenberg, M Schlather… - Interbull …, 2023 - madoc.bib.uni-mannheim.de
Abstract Single Nucleotide Polymorphism (SNP) genotype datasets used in empirical
research are steadily growing in size which has introduced challenges in the calculation of …

[HTML][HTML] Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes

Z Liang, D Prakapenka, Y Da - Biomolecules, 2023 - mdpi.com
The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global
epistasis effects was evaluated and compared to the accuracy of haplotype genomic …

Statistical Methods for Multi-Omic Integration and Optimization to Improve Trait Forecasting

V Manthena - 2022 - search.proquest.com
The development of genomic selection (GS) methods has allowed plant breeding programs
to select favorable lines using genomic data before performing field trials. Improvements in …