The coronavirus nucleocapsid is a multifunctional protein

R McBride, M Van Zyl, BC Fielding - Viruses, 2014 - mdpi.com
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic
RNA, interacts with the viral membrane protein during virion assembly and plays a critical …

The SARS coronavirus nucleocapsid protein–forms and functions

C Chang, MH Hou, CF Chang, CD Hsiao, T Huang - Antiviral research, 2014 - Elsevier
The nucleocapsid phosphoprotein of the severe acute respiratory syndrome coronavirus
(SARS-CoV N protein) packages the viral genome into a helical ribonucleocapsid (RNP) …

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

S Lu, Q Ye, D Singh, Y Cao, JK Diedrich… - Nature …, 2021 - nature.com
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …

Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy

BW Neuman, BD Adair, C Yoshioka, JD Quispe… - Journal of …, 2006 - Am Soc Microbiol
Coronavirus particles are enveloped and pleomorphic and are thus refractory to
crystallization and symmetry-assisted reconstruction. A novel methodology of single-particle …

The structural biology of PRRSV

T Dokland - Virus research, 2010 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, positive-
sense single-stranded RNA virus belonging to the Arteriviridae family. Arteriviruses and …

Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA

CY Chen, C Chang, YW Chang, SC Sue, HI Bai… - Journal of molecular …, 2007 - Elsevier
Coronavirus nucleocapsid proteins are basic proteins that encapsulate viral genomic RNA
to form part of the virus structure. The nucleocapsid protein of SARS-CoV is highly antigenic …

Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid …

CK Chang, YL Hsu, YH Chang, FA Chao… - Journal of …, 2009 - Am Soc Microbiol
The nucleocapsid protein (N) of the severe acute respiratory syndrome coronavirus (SARS-
CoV) packages the viral genomic RNA and is crucial for viability. However, the RNA-binding …

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein

KS Saikatendu, JS Joseph, V Subramanian… - Journal of …, 2007 - Am Soc Microbiol
Conserved among all coronaviruses are four structural proteins: the matrix (M), small
envelope (E), and spike (S) proteins that are embedded in the viral membrane and the …

Single-domain antibodies for the detection of SARS-CoV-2 nucleocapsid protein

GP Anderson, JL Liu, TJ Esparza, BT Voelker… - Analytical …, 2021 - ACS Publications
The goal of this work was to develop recombinantly expressed variable domains derived
from camelid heavy-chain antibodies known as single-domain antibodies (sdAbs) directed …

Transient oligomerization of the SARS-CoV N protein–implication for virus ribonucleoprotein packaging

C Chang, CMM Chen, M Chiang, Y Hsu, T Huang - PloS one, 2013 - journals.plos.org
The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus
(SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a …