ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

Cancer has been progressively a major global health concern. With this developing global
concern, cancer determent is one of the most significant public health challenges of this era …

Pancreatic cancer is a devastating disease with very poor prognosis. Currently, surgery
followed by adjuvant chemotherapy represents the only curative option which, unfortunately …

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains
one of the most aggressive malignancies, with remarkable resistance to treatment, poor …

Introduction Prognosis of patients with metastatic pancreatic ductal adenocarcinoma
(mPDAC) remains disappointing with a 5-year overall survival of only 3–5%. Compared to …

Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is
frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas …

Oxidative stress is one of the main causes of osteoblast apoptosis induced by post‑
menopausal osteoporosis. The authors previously found that metformin can reverse the loss …

In small molecule binding, water is not a passive bystander but rather takes an active role in
the binding site, which may be decisive for the potency of the inhibitor. Here, by addressing …

TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell
cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair …