The discovery of almost identical or 'stereotyped'B-cell receptor immunoglobulins (BcR IG)
among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of …

B cell receptor (BCR) signaling is a central pathway promoting the survival and proliferation
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

The concept of precision cell therapy targeting tumor-specific mutations is appealing but
requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of …

Twenty years after landmark publications, there is a consensus that the somatic
hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is …

Chronic lymphocytic leukemia (CLL) major stereotyped subset 2 (IGHV3-21/IGLV3-21,∼
2.5% of all cases of CLL) is an aggressive disease variant, irrespective of the somatic …

Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the
pathogenesis of chronic lymphocytic leukemia (CLL). Given the emerging multifarious …

Several types of B cell tumors, particularly MALT lymphomas, are known to have an antigen-
driven component in tumor development. Over the past two decades substantial data have …

Intraclonal diversification (ID) within the immunoglobulin (IG) genes expressed by B cell
clones arises due to ongoing somatic hypermutation (SHM) in a context of continuous …

With the advent of next-generation sequencing, the mutational landscape of chronic
lymphocytic leukemia (CLL) was rapidly unraveled with the discovery of recurrently mutated …