Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

MG Tirumala, P Anchi, S Raja, M Rachamalla… - Frontiers in …, 2021 - frontiersin.org
Nanotoxicology is an emerging field employed in the assessment of unintentional
hazardous effects produced by nanoparticles (NPs) impacting human health and the …

Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy

CR Wilcox, B Holder, CE Jones - Frontiers in immunology, 2017 - frontiersin.org
At birth, neonates are particularly vulnerable to infection and transplacental transfer of
immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of …

A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines

M Rothbauer, N Patel, H Gondola, M Siwetz… - Scientific reports, 2017 - nature.com
The human placenta plays a crucial role as the interface between mother and fetus. It
represents a unique tissue that undergoes morphological as well as functional changes on …

[HTML][HTML] A perspective on the developmental toxicity of inhaled nanoparticles

KS Hougaard, L Campagnolo, P Chavatte-Palmer… - Reproductive …, 2015 - Elsevier
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP)
may constitute a hazard to pregnancy and fetal development, primarily based on …

Placental transporter localization and expression in the human: the importance of species, sex, and gestational age differences

N Walker, P Filis, U Soffientini… - Biology of …, 2017 - academic.oup.com
The placenta is a critical organ during pregnancy, essential for the provision of an optimal
intrauterine environment, with fetal survival, growth, and development relying on correct …

Nanoparticle transport across the placental barrier: pushing the field forward!

C Muoth, L Aengenheister, M Kucki, P Wick… - …, 2016 - Taylor & Francis
The human placenta is a multifunctional organ constituting the barrier between maternal and
fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence …

An advanced human in vitro co-culture model for translocation studies across the placental barrier

L Aengenheister, K Keevend, C Muoth… - Scientific reports, 2018 - nature.com
Although various drugs, environmental pollutants and nanoparticles (NP) can cross the
human placental barrier and may harm the developing fetus, knowledge on predictive …

Placental control of drug delivery

S Al-Enazy, S Ali, N Albekairi, M El-Tawil… - Advanced drug delivery …, 2017 - Elsevier
The placenta serves as the interface between the maternal and fetal circulations and
regulates the transfer of oxygen, nutrients, and waste products. When exogenous …

Transfer and metabolism of the xenoestrogen zearalenone in human perfused placenta

B Warth, K Preindl, P Manser, P Wick… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Pregnancy is a sensitive condition during which adverse environmental
exposures should be monitored thoroughly and minimized whenever possible. In particular …

Early-life chemical exposures and risk of metabolic syndrome

NE De Long, AC Holloway - Diabetes, metabolic syndrome and …, 2017 - Taylor & Francis
The global prevalence of obesity has been increasing at a staggering pace, with few
indications of any decline, and is now one of the major public health challenges worldwide …