Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Biomarkers have transformed modern medicine but remain largely elusive in psychiatry,
partly because there is a weak correspondence between diagnostic labels and their …

Mental health researchers and clinicians have long sought answers to the question “What
works for whom?” The goal of precision medicine is to provide evidence-based answers to …

Intuition suggests that perception follows sensation and therefore bodily feelings originate in
the body. However, recent evidence goes against this logic: interoceptive experience may …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

In this paper, we integrate recent theoretical and empirical developments in predictive
coding and active inference accounts of interoception (including the Embodied Predictive …

Identification of intrinsic brain activity differences and similarities between major depression
(MDD) and bipolar disorder (BD) is necessary. However, results have not yet yielded …

Finding robust brain substrates of mood disorders is an important target for research. The
degree to which major depression (MDD) and bipolar disorder (BD) are associated with …

Johnson's pessimism notwithstanding, over the past five decades biomedical scientists have
made extraordinary progress, discovering causes and finding cures for both infectious and …