Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Systemic sclerosis (SSc) is a prototypical inflammatory fibrotic disease involving
inflammation, vascular abnormalities and fibrosis that primarily affect the skin and lungs. The …

Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue
homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant …

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in
fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although …

Systemic sclerosis (SSc) is a multisystem connective tissue disorder featured by vascular
injury and fibrosis of the skin and various internal organs with autoimmune background …

Systemic sclerosis (SS c) is a multisystem autoimmune disease characterized by
vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic …