Peptidergic systems and cancer: Focus on tachykinin and calcitonin/calcitonin gene-related peptide families

ML Sánchez, FD Rodríguez, R Coveñas - Cancers, 2023 - mdpi.com
Simple Summary Neurokinins A and B, adrenomedullin, adrenomedullin 2, amylin, and
calcitonin gene-related peptide are essential in different tumors. These peptides are …

Multi-biological functions of intermedin in diseases

Z Yang, H Li, P Wu, Q Li, CY Yu, D Wang… - Frontiers in Physiology, 2023 - frontiersin.org
Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT)
superfamily, and it is expressed extensively throughout the body. The typical receptors for …

Intermedin enlarges the vascular lumen by inducing the quiescent endothelial cell proliferation

L Wang, F Xiao, L Kong, D Wang, H Li… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Intermedin plays an important role in vascular remodeling and significantly
improves blood perfusion, but the precise mechanism remains unclear. Herein, we aimed to …

Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions

JT Kim, MA Lim, SE Lee, HJ Kim, HY Koh… - The Journal of …, 2022 - Wiley Online Library
Thyroid cancer is associated with genetic alterations, eg BRAFV600E, which may cause
carcinomatous changes in hormone‐secreting epithelial cells. Epidemiological studies have …

Treatment of prostate cancer cells with S-adenosylmethionine leads to genome-wide alterations in transcription profiles

T Schmidt, A Leha, G Salinas-Riester - Gene, 2016 - Elsevier
The hypomethylation of DNA may support tumor progression; however, the mechanism
underlying this relationship is not clear. Several studies have demonstrated that the in vitro …

Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation

L Kong, Y Xiong, D Wang, L Huang, M Li… - Breast Cancer Research …, 2022 - Springer
Purpose Breast cancer is the most frequently diagnosed cancer and is the leading cause of
cancer-associated mortality in women worldwide. Intermedin (IMD, also known as …

Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade

F Xiao, H Li, Z Feng, L Huang, L Kong, M Li, D Wang… - Scientific Reports, 2021 - nature.com
As one of the most malignant cancer types, hepatocellular carcinoma (HCC) is highly
invasive and capable of metastasizing to distant organs. Intermedin (IMD), an endogenous …

The role of the calcitonin peptide family in prostate cancer and bone metastasis

JI Warrington, GO Richards, N Wang - Current Molecular Biology Reports, 2017 - Springer
Abstract Purpose of Review This study is to highlight recent discoveries associated with the
role of calcitonin peptide family and their receptors in prostate cancer progression and bone …

Inhibition of intermedin (Adrenomedullin 2) suppresses the growth of glioblastoma and increases the antitumor activity of temozolomide

L Huang, D Wang, Z Feng, H Zhao, F Xiao, Y Wei… - Molecular Cancer …, 2021 - AACR
Glioblastoma multiforme (GBM; grade IV glioma) is the most malignant type of primary brain
tumor and is characterized by rapid proliferation and invasive growth. Intermedin (IMD) is an …

[HTML][HTML] The increased plasma levels of intermedin in patients with type 2 diabetes mellitus

F Liu, JT Duan, X Teng, DQ Peng - Acta Endocrinologica …, 2022 - ncbi.nlm.nih.gov
THE INCREASED PLASMA LEVELS OF INTERMEDIN IN PATIENTS WITH TYPE 2 DIABETES
MELLITUS - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …