The need for a quantitative and operator-independent assessment of coronary
microvascular function is increasingly recognized. We propose the theoretical framework of …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

The endothelium holds a pivotal role in cardiovascular health and disease. Assessment of
its function was until recently limited to experimental designs due to its location. The advent …

Background: A bolus thermodilution-derived index of microcirculatory resistance (IMR) has
emerged as the standard for assessing coronary microvascular dysfunction (CMD) …

Background—The principle of continuous thermodilution can be used to calculate absolute
coronary blood flow and microvascular resistance (R). The aim of the study is to explore the …

Coronary microvascular dysfunction is a highly prevalent condition of both structural and
functional coronary disorders in patients with angina and nonobstructive coronary artery …

Objectives: This study sought to investigate a novel method to calculate the index of
microcirculatory resistance (IMR) in the presence of significant epicardial stenosis without …

Coronary microvascular dysfunction is a highly prevalent condition in both obstructive and
nonobstructive coronary artery disease. Intracoronary thermodilution is a promising …

Women exhibit a greater symptom burden, more functional disability, and a higher
prevalence of no obstructive coronary artery disease compared to men when evaluated for …

Aims: The aim of this study is to validate a novel monorail infusion catheter for thermodilution-
based quantitative coronary flow measurements. Methods and results: Based on the …