HIV vaccines

AJ McMichael - Annu. Rev. Immunol., 2006 - annualreviews.org
A prophylactic vaccine for HIV-1 is badly needed. Despite 20 years of effort, it is still a long
way off. However, considerable progress has been made in understanding the problem. The …

[HTML][HTML] Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination

C Verheust, M Goossens, K Pauwels, D Breyer - Vaccine, 2012 - Elsevier
The modified vaccinia virus Ankara (MVA) strain is a highly attenuated strain of vaccinia
virus that has been demonstrated to be safe for humans. MVA is widely considered as the …

[HTML][HTML] The Brighton Collaboration standardized template for collection of key information for risk/benefit assessment of a Modified Vaccinia Ankara (MVA) vaccine …

A Volkmann, AL Williamson, H Weidenthaler… - Vaccine, 2021 - Elsevier
Abstract The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG)
was formed to evaluate the safety and characteristics of live, recombinant viral vector …

Safety, immunogenicity, and surrogate markers of clinical efficacy for modified vaccinia Ankara as a smallpox vaccine in HIV-infected subjects

RN Greenberg, ET Overton, DW Haas… - The Journal of …, 2013 - academic.oup.com
Background. Human immunodeficiency virus (HIV)–infected persons are at higher risk for
serious complications associated with traditional smallpox vaccines. Alternative smallpox …

Safety and immunogenicity of novel modified vaccinia Ankara-vectored RSV vaccine: A randomized phase I clinical trial

N Samy, D Reichhardt, D Schmidt, LM Chen… - Vaccine, 2020 - Elsevier
Respiratory disease caused by RSV infection is recognized as a severe public health issue
in infants, young children and elderly with no specific treatment option. Vaccination may be …

A recombinant MVA-based RSV vaccine induces T-cell and antibody responses that cooperate in the protection against RSV infection

K Endt, Y Wollmann, J Haug, C Bernig, M Feigl… - Frontiers in …, 2022 - frontiersin.org
Respiratory syncytial virus (RSV) causes a respiratory disease with a potentially fatal
outcome especially in infants and elderly individuals. Several vaccines failed in pivotal …

Vaccine-derived neutralizing antibodies to the human cytomegalovirus gH/gL pentamer potently block primary cytotrophoblast infection

F Chiuppesi, F Wussow, E Johnson, C Bian… - Journal of …, 2015 - Am Soc Microbiol
Human cytomegalovirus (HCMV) elicits neutralizing antibodies (NAb) of various potencies
and cell type specificities to prevent HCMV entry into fibroblasts (FB) and …

AIDS clinical trials group 5197: a placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing …

RT Schooley, J Spritzler, H Wang… - The Journal of …, 2010 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1)-specific cellular immunity
contributes to the control of HIV-1 replication. HIV-1-infected volunteers who were receiving …

IMVAMUNE®: modified vaccinia Ankara strain as an attenuated smallpox vaccine

JS Kennedy, RN Greenberg - Expert review of vaccines, 2009 - Taylor & Francis
Smallpox vaccines based on replicating vaccinia virus are known to elicit rare yet serious
adverse events, particularly in human populations with immune deficiency, atopic dermatitis …

Dendritic cell dysregulation during HIV‐1 infection

E Miller, N Bhardwaj - Immunological reviews, 2013 - Wiley Online Library
Dendritic cells (DC s) are a diverse subset of innate immune cells that are key regulators of
the host response to human immunodeficiency virus‐1 (HIV‐1) infection. HIV‐1 directly and …