Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and
a significant obstacle to improving patients' health and lives. Mitochondria are core …

Mitochondria are critical for the energetic demands of virtually every cellular process within
nucleated eukaryotic cells. They harbour multiple copies of their own genome (mtDNA), as …

Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

There are several types of mitochondrial cytopathies, which cause a set of disorders, arise
as a result of mitochondria's failure. Mitochondria's functional disruption leads to …

Mitochondrial genome (mitochondrial DNA, mtDNA) lesions that unbalance bioenergetic
and oxidative outputs are an important cause of human disease. A major impediment in our …

Aminoglycosides (AGs) are potent antibiotics that are capable of treating a wide variety of
life-threatening infections; however, they are ototoxic and cause irreversible damage to …

In this report, we investigated the pathophysiology of a novel hypertension-associated
mitochondrial tRNA Ala 5655A→ G (m. 5655A→ G) mutation. The destabilization of a highly …

Nuclear modifier gene (s) was proposed to modulate the phenotypic expression of
mitochondrial DNA mutation (s). Our previous investigations revealed that a nuclear modifier …

The role of metallic nano-and microparticles in the development of inflammation has not yet
been investigated. Soft tissue biopsy specimens of the bone bed taken during surgical …

In sepsis, bacterial components, particularly lipopolysaccharide (LPS), trigger organ injuries
such as liver dysfunction. Although sepsis induces hepatocyte damage, the mechanisms …