Collagens mediate essential hemostasis by maintaining the integrity and stability of the
vascular wall. Imbalanced turnover of collagens by uncontrolled formation and/or …

Our understanding of the genetic basis of myeloproliferative neoplasms began in 2005,
when the JAK2 (V617F) mutation was identified in polycythemia vera, essential …

The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-
dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus …

The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …

Bone marrow fibrosis is a critical component of primary myelofibrosis (PMF). However, the
origin of the myofibroblasts that drive fibrosis is unknown. Using genetic fate mapping we …

Megakaryocytes associate with the bone marrow vasculature where they convert their
cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen …

Myelofibrosis (MF) is a life-threatening blood cancer characterized by progressive bone
marrow fibrosis, splenomegaly, cytopenias, and debilitating constitutional symptoms …

In bone marrow, special microenvironments, known as niches, are essential for the
maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells …

During acute myelosuppression or thrombocytopenia, bone marrow (BM) hematopoietic
cells respond rapidly to replenish peripheral blood platelets. While the cytokine …

Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder
characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly …