Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …

Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the
context of human diseases associated with mutations in telomerase, such as some cases of …

Understanding the malleable determinants of cellular aging is critical to understanding
human longevity. Telomeres may provide a pathway for exploring this question. Telomeres …

Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …

Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

Telomeres are the DNA–protein complexes that protect the ends of eukaryotic
chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding …

Chronic stress can affect human health through a myriad of behavioral and biochemical
pathways. This review focuses on some key hormonal and metabolic pathways that appear …

Background. Leukocyte telomere length (LTL) is related to diseases of aging, but studies of
mortality have been inconsistent. Methods. We evaluated LTL in relation to total mortality …