Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-
inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Abstract mdash;: Sepsis remains a serious clinical problem despite intense efforts to
improve survival. Experimental animal models of sepsis have responded dramatically to …

Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host
survival by down-regulating the inflammatory response or, alternatively, harmful by impairing …

Clinical trials have provided information concerning the various immunological alterations
that occur after trauma which may cause the multiple organ dysfunction syndrome (MODS) …

Gram-negative sepsis is mediated by the actions of proinflammatory genes induced in
response to microbes and their products. We report that flagellin, the monomeric subunit of …

Background. Although it is well-known that excessive surgical stress augments the growth of
residual cancer and metastasis, whether surgical stress is increased according to the …

We investigated inflammatory and physiologic parameters in sepsis models of increasing
lethality induced by cecal ligation and puncture (CLP). Mice received imipenem for antibiotic …

Polymorphisms in the tumor necrosis factor and interleukin-10 genes, linked to cytokine
inducibility, may influence the inflammatory response to infection. We studied the biallelic …

Lethality from sepsis is believed to be mediated by a proinflammatory cytokine cascade, yet
blocking the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin …