Ferroptosis in hepatocellular carcinoma: from bench to bedside

D Tang, G Kroemer, R Kang - Hepatology, 2024 - journals.lww.com
The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

[HTML][HTML] Oxidative stress and hepatocarcinogenesis

Y Fu, FL Chung - Hepatoma research, 2018 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths
worldwide. There are two major challenges for HCC, the first being that early detection is …

Epigallocatechin gallate induces hepatic stellate cell senescence and attenuates development of hepatocellular carcinoma

M Sojoodi, L Wei, DJ Erstad, S Yamada, T Fujii… - Cancer Prevention …, 2020 - AACR
Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment
options. HCC arises from chronically inflamed and damaged liver tissue; therefore …

Cell division cycle‐associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma

H Wu, S Liu, D Wu, H Zhou, G Sui, G Wu - Cancer Medicine, 2023 - Wiley Online Library
Background Cell division cycle‐associated 8 (CDCA8) is involved in numerous signaling
networks, and it serves a crucial modulatory function in multiple malignant tumors. However …

[HTML][HTML] Branched-chain amino acids and l-carnitine attenuate lipotoxic hepatocellular damage in rat cirrhotic liver

Y Tamai, Z Chen, Y Wu, J Okabe, Y Kobayashi… - Biomedicine & …, 2021 - Elsevier
Branched-chain amino acids (BCAA) reverse malnutrition and l-carnitine leads to the
reduction of hyperammonemia and muscle cramps in cirrhotic patients. BCAA and l-carnitine …

Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma

N Wang, Y Li, X Zhou, X Wang, G Yang - Computers in Biology and …, 2023 - Elsevier
Lung adenocarcinoma (LUAD), the most common histological type in lung cancer, is one of
leading cancers with considerable morbidity/mortality worldwide. Treating LUAD remains an …

Htra2 independently predicts poor prognosis and correlates with immune cell infiltration in hepatocellular carcinoma

L Feng, Z Li, Y Xiong, T Yan, C Fu, Q Zeng… - Journal of …, 2023 - Wiley Online Library
High‐temperature requirement protein A2 (HtrA2), a mitochondrial protein, is related to
apoptosis regulation. However, the role of HtrA2 in hepatocellular carcinoma (HCC) remains …

Theaphenon E prevents fatty liver disease and increases CD4+ T cell survival in mice fed a high-fat diet

H Coia, N Ma, Y Hou, E Permaul, DL Berry, MI Cruz… - Clinical Nutrition, 2021 - Elsevier
Background & aims Obesity is a major cause of non-alcoholic fatty liver disease (NAFLD).
NAFLD is an epidemic affecting nearly 34% of the adult population in the US. As a chronic …

[HTML][HTML] The lipid peroxidation-derived DNA adduct γ-OHPdG as a diagnostic and prognostic biomarker in hepatocellular carcinoma

Q Cao, Y Zhang, H Liu, Y Cheng, M Liu, H Zhao… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Purpose: Chronic inflammation and lipid peroxidation (LPO) are associated with the
pathogenesis of hepatocellular carcinoma (HCC), and γ-hydroxy-1, N 2 …

[HTML][HTML] Identification and validation of methylation-CpG prognostic signature for prognosis of hepatocellular carcinoma

C He, Z Guo, H Zhang, G Yang, J Gao, Z Mo - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Epigenetic biomarkers help predict the prognosis of cancer patients and evaluating the
clinical outcome of immunization therapy. In this study, we present a personalized gene …