Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Cryptococcus neoformans is an encapsulated fungal pathogen that causes infection in
immunocompromised individuals such as HIV patients, organ transplant patients …

The granule exocytosis pathway of cytotoxic lymphocytes is crucial for immune surveillance
and homeostasis. The trafficking of granule components, including the membrane-disruptive …

Forming the first line of defence against virally infected and malignant cells, natural killer
(NK) cells are critical effector cells of the innate immune system. With age, significant …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Natural killer (NK) cells are well recognized for their ability to provide a first line of defence
against viral pathogens and they are increasingly being implicated in immune responses …

Opportunistic pathogens have become of increasing medical importance over the last
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …

Granulysin is a cytolytic and proinflammatory molecule first identified by a screen for genes
expressed 'late'(3–5 days) after activation of human peripheral blood mononuclear cells …

We studied the role of NK cell-activating receptors and their ligands in the lysis of
mononuclear phagocytes infected with the intracellular pathogen Mycobacterium …

We previously showed that human NK cells used the NKp46 receptor to lyse Mycobacterium
tuberculosis H37Ra-infected monocytes. To identify ligands on H37Ra-infected human …