γ‐Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex,
maintains the inhibitory tone that counterbalances neuronal excitation. When this balance is …

Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction
among neuronal networks in limbic structures such as the hippocampus, amygdala and …

Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …

The dentate granule cell layer of the rodent hippocampal formation has the distinctive
property of ongoing neurogenesis that continues throughout adult life. In both human …

Glutamate decarboxylase (GAD) catalyzes the production of γ‐aminobutyric acid (GABA), a
major inhibitory neurotransmitter. The mammalian brain contains two forms of GAD, with Ms …

Patient RB (Human amnesia and the medial temporal region: enduring memory impairment
following a bilaterial lesion limited to field CA1 of the hippocampus, S. Zola-Morgan, LR …

The distribution of granule cells in the dentate gyrus of the hippocampal formation was
studied in control autopsy and temporal lobe epilepsy (TLE) specimens. In control tissue, the …

The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing
neurons, suggesting its possible role in vesicular zinc transport. We show here that …

We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the
time course of supragranular dentate sprouting and to assess the relation between several …

The relationship between an episode of status epilepticus, the resulting hippocampal
pathology, and the subsequent development of pathophysiological changes possibly …