From rabbit antibody repertoires to rabbit monoclonal antibodies

J Weber, H Peng, C Rader - Experimental & molecular medicine, 2017 - nature.com
In this review, we explain why and how rabbit monoclonal antibodies have become
outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic …

Role of complement and complement regulatory proteins in the complications of diabetes

P Ghosh, R Sahoo, A Vaidya, M Chorev… - Endocrine …, 2015 - academic.oup.com
It is well established that the organ damage that complicates human diabetes is caused by
prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels …

[HTML][HTML] Diabetic retinopathy and dysregulated innate immunity

H Xu, M Chen - Vision Research, 2017 - Elsevier
Diabetic retinopathy (DR) is the progressive degeneration of retinal blood vessels and
neurons. Inflammation is known to play an important role in the pathogenesis of DR. During …

Novel biochemical markers of glycemia to predict pregnancy outcomes in women with type 1 diabetes

CL Meek, D Tundidor, DS Feig, JM Yamamoto… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE The optimal method of monitoring glycemia in pregnant women with type 1
diabetes remains controversial. This study aimed to assess the predictive performance of …

[HTML][HTML] Complement activation in patients with diabetic nephropathy

P Bus, JS Chua, CQF Klessens, M Zandbergen… - Kidney International …, 2018 - Elsevier
Introduction Complement activation plays a role in various organs in patients with diabetes.
However, in diabetic nephropathy (DN), the role of complement activation is poorly …

(Patho) physiology of glycosylphosphatidylinositol-anchored proteins I: Localization at plasma membranes and extracellular compartments

GA Müller, TD Müller - Biomolecules, 2023 - mdpi.com
Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of plasma membranes (PMs) of all eukaryotic organisms studied so far by covalent linkage …

Enrichment and analysis of glycated proteins

S Cho, VA Duong, JH Mok, M Joo, JM Park… - Reviews in Analytical …, 2022 - degruyter.com
Glycation is a spontaneous post-translational modification of lysine, arginine, and the N-
terminus of proteins. Protein glycation is closely related to the pathogenesis of human …

The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues

M Staniszewska, A Bronowicka-Szydełko… - Scientific Reports, 2021 - nature.com
Non-enzymatic modification of proteins by carbohydrates, known as glycation, leads to
generation of advanced glycation end-products (AGEs). In our study we used in vitro …

The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events

U Krus, BC King, V Nagaraj, NR Gandasi, J Sjölander… - Cell metabolism, 2014 - cell.com
Type 2 diabetes is triggered by reduced insulin production, caused by genetic and
environmental factors such as inflammation originating from the innate immune system …

Plasma glycated CD59 predicts early gestational diabetes and large for gestational age newborns

DD Ma, MA Luque-Fernandez… - The Journal of …, 2020 - academic.oup.com
Context Gestational diabetes mellitus (GDM) diagnosed in early pregnancy is a health care
challenge because it increases the risk of adverse outcomes. Plasma-glycated CD59 …