Although long noncoding RNAs (lncRNAs) are generally expressed at low levels, emerging
evidence has revealed that many play important roles in gene regulation by a variety of …

Slight modifications of chromatin dynamics can translate into small-and large-scale changes
in DNA replication and DNA repair. Similarly, promoter usage and accessibility are tightly …

Mitotic chromosome formation involves a relatively minor condensation of the chromatin
volume coupled with a dramatic reorganization into the characteristic “X” shape. Here we …

The human nuclear poly (A)-binding protein PABPN1 has been implicated in the decay of
nuclear noncoding RNAs (ncRNAs). In addition, PABPN1 promotes hyperadenylation by …

Subnuclear organization and spatiotemporal regulation of pre-mRNA processing factors is
essential for the production of mature protein-coding mRNAs. We have discovered that a …

Epigenetic dysregulation of chromatin is one of the hallmarks of cancer development and
progression, and it is continuously investigated as a potential general bio-marker of this …

Eukaryotic genomes are highly ordered through various mechanisms, including
topologically associating domain (TAD) organization. We employed an in situ Hi-C approach …

Senescence is induced by various stimuli such as oncogene expression and telomere
shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence …

Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces promiscuous
expression of thousands of tissue‐restricted antigens (TRAs) in medullary thymic epithelial …

Stem cells are essential for development and tissue maintenance and display molecular
markers and functions distinct from those of differentiated cell types in a given tissue …