Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Human telomeres are tandem arrays that are predominantly composed of 5′-TTAGGG-3′
nucleotide sequences at the terminal ends of chromosomes. These sequences serve 2 …

Increased neddylation benefits the survival of several types of cancer cells. The inhibition of
neddylation has the potential to exert anticancer effects but is rarely assessed in oral cancer …

The incidence of diabetes is increasing annually, and the disease is uncurable due to its
complex pathogenesis. Therefore, understanding diabetes pathogenesis and developing …

Background The use of mobilizing agents for hematopoietic stem cell (HSC) transplantation
is insufficient for an increasing number of patients. We previously reported lipid made …

Triple-negative breast cancer (TNBC) is a subtype of breast tumor with the highest breast
cancer stem cells (BCSCs) content and resistance to conventional treatment. Due to the …

Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in
cellular immortalization and the development and progression of the tumor. Chemical …

Disease relapse is a common cause of treatment failure in FMS-like tyrosine kinase 3 (FLT3)
mutated acute myeloid leukemia (AML). In this study, to identify therapeutic targets …

SARS‐CoV‐2 first raised from Wuhan City, Hubei Province in November 2019. The
respiratory disorder, cough, weakness, fever are the main clinical symptoms of coronavirus …

Simple Summary Blocking telomerase to drive telomere erosion-dependent antiproliferative
effects in cancer cells appears impractical. However, the evidence of extra-telomeric …