UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

Abstract 3D cultures of primary human hepatocytes (PHH) are emerging as a more in vivo-
like culture system than previously available hepatic models. This work describes the …

The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and
UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and …

UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that
metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many …

Aims: Carvedilol is an effective treatment in hypertension and chronic heart failure. The
medical impact of polymorphisms in CYP2D6 and in the β-adrenergic receptors ADRB1 and …

The response to β blockers in patients with heart failure could be associated with the
genotype of drug-metabolizing enzymes and/or drug targets. The purpose of the present …

Carvedilol is a commonly used antihypertensive whose oral absorption is limited by low
solubility and significant first-pass metabolism. This work aimed to apply chemometrics for …