A core challenge in biomedical and life science research is to decipher cell-to-cell
differences under pathological progression or external perturbation. Microfluidics-based …

The number of studies investigating the human gastrointestinal tract using various single-
cell profiling methods has increased substantially in the past few years. Although this …

Alzheimer's disease (AD) is a multifaceted neurodegenerative condition marked by gradual
cognitive deterioration and the loss of neurons. While conventional bulk RNA sequencing …

Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and
proteomic measurements from the same samples with the goal of fully understanding the …

Expression levels of microRNAs (miRNAs) in single cells are low and conventional miRNA
detection methods require amplification that can be complex, time-consuming, costly and …

The inherent heterogeneity of individual cells in cell populations plays significant roles in
disease development and progression, which is critical for disease diagnosis and treatment …

The recent advent of sophisticated technologies like sequencing and mass spectroscopy
platforms combined with artificial intelligence-powered analytic tools has initiated a new era …

The ovary is a female reproductive organ that plays a key role in fertility and the
maintenance of endocrine homeostasis, which is of great importance to women's health. It is …

As one of the most lethal cancers, primary liver cancer (PLC) has high tumor heterogeneity,
including the heterogeneity between cancer cells. Traditional methods which have been …

Single-cell analysis provides an overwhelming strategy for revealing cellular heterogeneity
and new perspectives for understanding the biological function and disease mechanism …