The gut microbiota and its biogeography

G McCallum, C Tropini - Nature Reviews Microbiology, 2024 - nature.com
Biogeography is the study of species distribution and diversity within an ecosystem and is at
the core of how we understand ecosystem dynamics and interactions at the macroscale. In …

Vagus nerve as modulator of the brain–gut axis in psychiatric and inflammatory disorders

S Breit, A Kupferberg, G Rogler, G Hasler - Frontiers in psychiatry, 2018 - frontiersin.org
The vagus nerve represents the main component of the parasympathetic nervous system,
which oversees a vast array of crucial bodily functions, including control of mood, immune …

Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization

FC Pereira, K Wasmund, I Cobankovic… - Nature …, 2020 - nature.com
Many intestinal pathogens, including Clostridioides difficile, use mucus-derived sugars as
crucial nutrients in the gut. Commensals that compete with pathogens for such nutrients are …

Chemical transformation of xenobiotics by the human gut microbiota

N Koppel, V Maini Rekdal, EP Balskus - Science, 2017 - science.org
BACKGROUND Humans ingest a multitude of small molecules that are foreign to the body
(xenobiotics), including dietary components, environmental chemicals, and …

Co-evolution and co-speciation of host-gut bacteria systems

M Groussin, F Mazel, EJ Alm - Cell Host & Microbe, 2020 - cell.com
Mammalian gut microbiomes profoundly influence host fitness, but the processes that drive
the evolution of host-microbiome systems are poorly understood. Recent studies suggest …

Gut biogeography of the bacterial microbiota

GP Donaldson, SM Lee, SK Mazmanian - Nature Reviews Microbiology, 2016 - nature.com
Animals assemble and maintain a diverse but host-specific gut microbial community. In
addition to characteristic microbial compositions along the longitudinal axis of the intestines …

The gut microbiota influences anticancer immunosurveillance and general health

B Routy, V Gopalakrishnan, R Daillère… - Nature Reviews …, 2018 - nature.com
Discoveries made in the past 5 years indicate that the composition of the intestinal
microbiota has a major influence on the effectiveness of anticancer immunosurveillance and …

The gut microbiome: connecting spatial organization to function

C Tropini, KA Earle, KC Huang, JL Sonnenburg - Cell host & microbe, 2017 - cell.com
The first rudimentary evidence that the human body harbors a microbiota hinted at the
complexity of host-associated microbial ecosystems. Now, almost 400 years later, a …

Akkermansia muciniphila and its role in regulating host functions

M Derrien, C Belzer, WM de Vos - Microbial pathogenesis, 2017 - Elsevier
Akkermansia muciniphila is an intestinal bacterium that was isolated a decade ago from a
human fecal sample. Its specialization in mucin degradation makes it a key organism at the …

Conditioning of the immune system by the microbiome

DB Graham, RJ Xavier - Trends in Immunology, 2023 - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …