Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of
cellular energy status in cancers and is critically involved in cell sensitivity to anticancer …

Selective drug delivery is an important approach with great potential for overcoming
problems associated with the systemic toxicity and poor bioavailability of antineoplastic …

The mammalian target of rapamycin (mTOR) is responsive to numerous extracellular and
intracellular cues and, through the formation of two physically and functionally distinct …

Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic
large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express …

Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor
(EGFR) are highly responsive to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib …

Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …

Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent
occurrence in human cancers and a major promoter of chemotherapeutic resistance …

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …