Kallikrein-kinin system mediated inflammation in Alzheimer's disease in vivo
The Kallikrein-Kinin System (KKS) has been associated to inflammatory and immunogenic
responses in the peripheral and central nervous system by the activation of two receptors …
responses in the peripheral and central nervous system by the activation of two receptors …
Renaissance in peptide drug discovery: the third wave
TK Sawyer - 2017 - books.rsc.org
Chapter 1 2 mechanisms and peptide drug delivery, including cell permeability to prosecute
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …
Increases of kinin B1 and B2 receptors binding sites after brain infusion of amyloid-beta 1–40 peptide in rats
TA Viel, AL Caetano, AG Nasello, CL Lancelotti… - Neurobiology of …, 2008 - Elsevier
Although numerous inflammation pathways have been implicated in Alzheimer's disease,
the involvement of the kallikrein–kinin system is still under investigation. We anatomically …
the involvement of the kallikrein–kinin system is still under investigation. We anatomically …
Autoradiographic analysis of rat brain kinin B1 and B2 receptors: Normal distribution and alterations induced by epilepsy
B Ongali, MM Campos, G Bregola… - Journal of …, 2003 - Wiley Online Library
Kindling‐induced seizures constitute an experimental model of human temporal lobe
epilepsy that is associated with changes in the expression of several inflammatory proteins …
epilepsy that is associated with changes in the expression of several inflammatory proteins …
Bombesin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
J Battey, RV Benya, RT Jensen… - IUPHAR/BPS Guide to …, 2019 - journals.ed.ac.uk
Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB 1, BB 2, BB 3 (nomenclature
recommended by the NC-IUPHAR Subcommittee on bombesin receptors,[109]). BB 1 and …
recommended by the NC-IUPHAR Subcommittee on bombesin receptors,[109]). BB 1 and …
[引用][C] International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences
LMF Leeb-Lundberg, F Marceau, W Müller-Esterl… - Pharmacological …, 2005 - ASPET
Targeting kinin receptors for the treatment of neurological diseases
D Rodi, R Couture, B Ongali… - Current pharmaceutical …, 2005 - ingentaconnect.com
Kinins (bradykinin, kallidin and their active metabolites) are peptide autacoids with
established functions in cardiovascular homeostasis, contraction and relaxation of smooth …
established functions in cardiovascular homeostasis, contraction and relaxation of smooth …
Role of kinin B1 and B2 receptors in memory consolidation during the aging process of mice
MTR Lemos, FA Amaral, KE Dong, MFQP Bittencourt… - Neuropeptides, 2010 - Elsevier
Under physiological conditions, elderly people present memory deficit associated with
neuronal loss. This pattern is also associated with Alzheimer's disease but, in this case, in a …
neuronal loss. This pattern is also associated with Alzheimer's disease but, in this case, in a …
Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats
F Cloutier, B Ongali, MM Campos… - British journal of …, 2004 - Wiley Online Library
Intracerebroventricular (icv) effects of bradykinin (BK) B1 and B2 receptor agonists and
antagonists were assessed on mean arterial blood pressure (MAP) and heart rate (HR) in …
antagonists were assessed on mean arterial blood pressure (MAP) and heart rate (HR) in …
Kinin receptors in cultured rat microglia
M Noda, Y Kariura, T Amano, Y Manago… - Neurochemistry …, 2004 - Elsevier
Kinins are produced and act at the site of injury and inflammation in various tissues. They
are likely to initiate a particular cascade of inflammatory events, which evokes physiological …
are likely to initiate a particular cascade of inflammatory events, which evokes physiological …