Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
MetaboLights: open data repository for metabolomics
O Yurekten, T Payne, N Tejera… - Nucleic acids …, 2024 - academic.oup.com
MetaboLights is a global database for metabolomics studies including the raw experimental
data and the associated metadata. The database is cross-species and cross-technique and …
data and the associated metadata. The database is cross-species and cross-technique and …
Methods in marine natural product drug discovery: what's new?
J Almaliti, WH Gerwick - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Natural products (NPs) remain as a leading source of new inspirational scaffolds and
pharmacophores for the development of pharmaceuticals. Marine organisms, while still …
pharmacophores for the development of pharmaceuticals. Marine organisms, while still …
Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics
Despite the increasing availability of tandem mass spectrometry (MS/MS) community
spectral libraries for untargeted metabolomics over the past decade, the majority of acquired …
spectral libraries for untargeted metabolomics over the past decade, the majority of acquired …
Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans
Untargeted metabolomics via high-resolution mass spectrometry can reveal more than
100,000 molecular features in a single sample, many of which may represent unidentified …
100,000 molecular features in a single sample, many of which may represent unidentified …
Evaluation of data-dependent MS/MS acquisition parameters for non-targeted metabolomics and molecular networking of environmental samples: Focus on the Q …
Non-targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) is a widely
used tool for metabolomics analysis, enabling the detection and annotation of small …
used tool for metabolomics analysis, enabling the detection and annotation of small …
Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides
Antibiotics are central to modern medicine, and yet they are mainly the products of intra and
inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a …
inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a …
Marine dissolved organic matter: a vast and unexplored molecular space
Marine dissolved organic matter (DOM) comprises a vast and unexplored molecular space.
Most of it resided in the oceans for thousands of years. It is among the most diverse …
Most of it resided in the oceans for thousands of years. It is among the most diverse …
From MS/MS library implementation to molecular networks: Exploring oxylipin diversity with NEO-MSMS
A Elloumi, L Mas-Normand, J Bride, G Reversat… - Scientific Data, 2024 - nature.com
Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids
(PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology …
(PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology …
A practical guide to interpreting and generating bottom‐up proteomics data visualizations
Mass‐spectrometry based bottom‐up proteomics is the main method to analyze proteomes
comprehensively and the rapid evolution of instrumentation and data analysis has made the …
comprehensively and the rapid evolution of instrumentation and data analysis has made the …