The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Hereditary channelopathies, that is, mutations in channel genes that alter channel function
and are causal for the pathogenesis of the disease, have been described for several …

Insect meals are novel and potentially sustainable protein sources. The objectives of this
study were to determine the chemical composition and standardized amino acid digestibility …

Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

The distal hereditary motor neuropathies (dHMN) comprise a heterogenous group of
diseases that share the common feature of a length-dependent predominantly motor …

Sustained increase in intraocular pressure represents a major risk factor for eye disease, yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …

Transient receptor potential channels, of the vanilloid subtype (TRPV), act as sensory
mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress …

The widely distributed TRPV4 cationic channel participates in the transduction of both
physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and …

Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …

Evidence accumulated over recent years has shown that genetic neurological
channelopathies can cause many different neurological diseases. Presentations relating to …