Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …

Deubiquitinating enzymes (DUBs) are an emerging drug target class of~ 100 proteases that
cleave ubiquitin from protein substrates to regulate many cellular processes. A lack of …

Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and
represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential …

The ubiquitin/proteasome system is a primary conduit for selective intracellular protein
degradation. Since its discovery over 30 years ago, this highly regulated system continues to …

Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset
Alzheimer's disease (AD), implicating key roles for chromosome 21–encoded genes in the …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk
factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS …

Cancer is a disorder of cell growth and proliferation, characterized by different metabolic
pathways within normal cells. The Warburg effect is a major metabolic process in cancer …