Glial cells, consisting of microglia, astrocytes and oligodendrocyte lineage cells as their
major components, constitute a large fraction of the mammalian brain. Originally considered …

Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in
response to all CNS injuries and diseases. To better understand the reactive astrocyte state …

Acute seizures after a severe brain insult can often lead to epilepsy and cognitive
impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult …

Astrocytes maintain the homeostasis of the central nervous system (CNS) by eg recycling of
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …

The adult mammalian subventricular zone (SVZ) contains stem cells that give rise to
neurons and glia. In vivo, SVZ progeny migrate 3–8 mm to the olfactory bulb, where they …

For several decades, the reactive gliosis that occurs after an injury to the CNS has been
considered one of the major impediments to axonal regeneration. Nevertheless, recent …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Reactive astrocytes (RAs) have been reported to convert to multipotent neural stem cells
(NSCs) capable of neurosphere (NS) formation and multilineage differentiation in vitro …