Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors

M Ocan, D Akena, S Nsobya, MR Kamya, R Senono… - Malaria journal, 2019 - Springer
Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Drug resistance of Plasmodium falciparum and Plasmodium vivax isolates in Indonesia

FV Rahmasari, PBS Asih, FK Dewayanti… - Malaria Journal, 2022 - Springer
This review article aims to investigate the genotypic profiles of Plasmodium falciparum and
Plasmodium vivax isolates collected across a wide geographic region and their association …

Genetic Diversity of Plasmodium falciparum Populations in Malaria Declining Areas of Sabah, East Malaysia

MR Mohd Abd Razak, UR Sastu, NA Norahmad… - PloS one, 2016 - journals.plos.org
Malaysia has a national goal to eliminate malaria by 2020. Understanding the genetic
diversity of malaria parasites in residual transmission foci can provide invaluable information …

High prevalence of Pfcrt 76T and Pfmdr1 N86 genotypes in malaria infected patients attending health facilities in East Shewa zone, Oromia Regional State, Ethiopia

J Hassen, GS Alemayehu, H Dinka, L Golassa - Malaria Journal, 2022 - Springer
Background Plasmodium falciparum resistance to series of anti-malarial drugs is a major
challenge in efforts to control and/or eliminate malaria globally. In 1998, following the …

Molecular analysis of bio-makers of chloroquine resistance in Plasmodium falciparum isolate from Gombe local government area, Gombe State, Nigeria

I Muhammad, PM Sale, MK Salisu… - Cellular, Molecular …, 2022 - cmbr-journal.com
Chloroquine was one of the most cheapest and effective chemotherapeutic drugs for
Plasmodium falciparum-malaria, but for a long, the drug has been officially withdrawn in …

Role of Different Pfcrt and Pfmdr‐1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum

ZO Ibraheem, R Abd Majid, SM Noor… - Malaria research …, 2014 - Wiley Online Library
Emergence of drugs resistant strains of Plasmodium falciparum has augmented the scourge
of malaria in endemic areas. Antimalaria drugs act on different intracellular targets. The …

Plasmodium falciparum population structure inferred by msp1 amplicon sequencing of parasites collected from febrile patients in Kenya

B Andika, V Mobegi, K Gathii, J Nyataya, N Maina… - Malaria Journal, 2023 - Springer
Background Multiplicity of infection (MOI) is an important measure of Plasmodium falciparum
diversity, usually derived from the highly polymorphic genes, such as msp1, msp2 and glurp …

Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar

R Zomuanpuii, CL Hmar, K Lallawmzuala, L Hlimpuia… - Malaria journal, 2020 - Springer
Background Mizoram, a northeastern state in India, shares international borders with
Myanmar and Bangladesh and is considered to be one of the key routes through which drug …

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs …

FT Foguim, H Bogreau, M Gendrot, J Mosnier, I Fonta… - Malaria Journal, 2020 - Springer
Abstract Background The Plasmodium falciparum chloroquine transporter gene (pfcrt) is
known to be involved in chloroquine and amodiaquine resistance, and more particularly the …

Asymptomatic malaria infections and Pfmdr1 mutations in an endemic area of Nigeria

TM Dokunmu, CU Adjekukor, OF Yakubu, AO Bello… - Malaria Journal, 2019 - Springer
Background Malaria eradication globally is yet to be achieved and transmission is sustained
in many endemic countries. Plasmodium falciparum continues to develop resistance to …