People aged 60 and older represent over 11% of the world population and it is expected to
rise 22% by 2050. Population aging is associated to an increased frequency of age-related …

The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people
worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious …

The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but
surprisingly little is known about relative severity of infectious disease between the extremes …

T cell responses to viruses are initiated and maintained in tissue sites; however, knowledge
of human antiviral T cells is largely derived from blood. Cytomegalovirus (CMV) persists in …

Human immunodeficiency virus (HIV)–infected adults who take stable antiretroviral therapy
(ART) are at risk for early onset of age-related diseases. This is likely due to a complex …

A history of Childhood Maltreatment (CM) has been repeatedly associated with an increased
risk of developing bipolar disorders (BD) or schizophrenia (SZ). The impact of severe stress …

Advancing age is characterized by functional and phenotypic alterations in the distribution of
circulating T-cell subsets, some of which are exacerbated by a latent infection with the …

In the year 2000, cytomegalovirus was identified as a risk factor for mortality in a seminal
study of octogenarian residents in Sweden. This finding triggered a wave of additional …