Introduction: Inflammatory bowel disease (IBD) is a systemic disease with immune
abnormalities that can affect the entire digestive tract. A high percentage of patients with IBD …

Tumor-associated macrophages (TAMs) express programmed cell death ligand 1 (PD-L1)
and contribute to the immune-suppressive tumor microenvironment. Although the role of the …

The adult myocardium has a limited regenerative capacity following heart injury, and the lost
cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical …

Using a functional approach to investigate the epigenetics of type 2 diabetes (T2D), we
combine three lines of evidence—diet-induced epigenetic dysregulation in mouse …

Background Histone lysine demethylase 4B (KDM4B) has been implicated in various
pathological processes and human diseases. Glucose metabolism is the main pattern of …

Abstract Background and Aims: Aberrant transcriptional programs are highly regulated
processes that play important roles in the development and progression of hepatocellular …

Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could
promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …

Osteosarcoma is the most common primary bone tumor in children and adolescents. Many
patients with osteosarcoma always develop drug resistance to current chemotherapy …

Objectives Casein kinase 2 interacting protein-1 (CKIP-1) is a versatile player involved in
various biological processes. However, whether CKIP-1 mediates the osteogenic …

Neddylation, an important type of post-translational modification, has been implicated in
innate and adapted immunity. But the role of neddylation in innate immune response against …