We have developed workflows to align 3D magnetic resonance histology (MRH) of the
mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen …

Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant.
One of the most important long-term complications observed in children who survive NEC …

Tissue microstructure modeling of diffusion MRI signal is an active research area striving to
bridge the gap between macroscopic MRI resolution and cellular-level tissue architecture …

The fiber g-ratio is defined as the ratio of the inner to the outer diameter of the myelin sheath.
This ratio provides a measure of the myelin thickness that complements axon morphology …

Previous studies have demonstrated myelin deficits in Alzheimer's disease (AD). However, it
is still unclear whether myelin deficits occur at early stage of AD. Our study aimed to …

Corpus callosum malformations are associated with a broad range of neurodevelopmental
diseases. We report that de novo mutations in MAST1 cause mega-corpus-callosum …

Purpose To investigate diffusion‐time dependency of diffusional kurtosis in the mouse brain
using pulsed‐gradient spin‐echo (PGSE) and oscillating‐gradient spin‐echo (OGSE) …

Objectives Multiple sclerosis (MS) is a neurodegenerative disease characterised by
inflammation and damage to the myelin sheath, resulting in physical and cognitive disability …

Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical
studies to characterize tissue microstructure and structural connectivity. The diffusion MRI …