Hox genes play key roles in axial patterning and regulating the regional identity of cells and
tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox …

Hox genes encode evolutionarily conserved transcription factors that are essential for the
proper development of bilaterian organisms. Hox genes are unique because they are …

The chromosomally-arrayed Hox gene family plays central roles in embryonic patterning
and the specification of cell identities throughout the animal kingdom. In vertebrates, the …

Most current single-cell analysis pipelines are limited to cell embeddings and rely heavily on
clustering, while lacking the ability to explicitly model interactions between different feature …

Precise Hox gene expression is crucial for embryonic patterning. Intra-Hox transcription
factor binding and distal enhancer elements have emerged as the major regulatory modules …

Hox proteins are homeodomain transcription factors that diversify serially homologous
segments along the animal body axis, as revealed by the classic bithorax phenotype of …

Abstract Development of the malaria parasite, Plasmodium falciparum, is regulated by a
limited number of sequence-specific transcription factors (TFs). However, the mechanisms …

Loss of Cdx2 in vivo leads to stunted development of the allantois, an extraembryonic
mesoderm-derived structure critical for nutrient delivery and waste removal in the early …

The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet
have nearly identical DNA binding specificities. To identify mechanisms that facilitate …

Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early
fate decisions by establishing heritable patterns of gene repression. PRCs repress …