▪ Abstract The cerebellum is an evolutionarily conserved structure critical for motor learning
in vertebrates. The model that has influenced much of the work in the field for the past 30 …

This review examines vestibular compensation and vestibular rehabilitation from a unified
translational research perspective. Laboratory studies illustrate neurobiological principles of …

Adaptation of ocular reflexes is a prototype of motor learning. While the cerebellum is
acknowledged as the critical site for motor learning, the functional differences between the …

Patients with bilateral vestibulopathy (BV) suffer from persistent postural imbalance, leading
to a marked decrease in quality of life and a higher risk of falls. However, so far, the effective …

Induction of cerebellar long-term depression (LTD) requires a postsynaptic cascade
involving activation of mGluR1 and protein kinase C (PKC). Our understanding of this …

Cerebellar climbing fiber activity encodes performance errors during many motor learning
tasks, but the role of these error signals in learning has been controversial. We compared …

The vestibular system provides an attractive model for understanding how changes in
cellular and synaptic activity influence learning and memory in a quantifiable behavior, the …

Long-lasting memories are formed when the stimulus is temporally distributed (spacing
effect). However, the synaptic mechanisms underlying this robust phenomenon and the …

Cerebellar motor learning is suggested to be caused by long-term plasticity of excitatory
parallel fiber-Purkinje cell (PF–PC) synapses associated with changes in the number of …

The cerebellum influences behavior and cognition exclusively via Purkinje cell synapses
onto neurons in the deep cerebellar and vestibular nuclei. In contrast with the rich …