A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy
The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …
The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches
Adenosine is an ubiquitous local modulator that regulates various physiological and
pathological functions by stimulating four membrane receptors, namely A1, A2A, A2B, and …
pathological functions by stimulating four membrane receptors, namely A1, A2A, A2B, and …
Synthesis and structural characterization of nickel (II) complexes supported by pyridine-functionalized N-heterocyclic carbene ligands and their catalytic acitivities for …
The imidazolium salts bis (N-pyridylimidazoliumyl) methane hexafluorophosphate
([H2L1](PF6) 2) and bis (N-picolyl) benzimidazoliumyl) methane hexafluorophosphate …
([H2L1](PF6) 2) and bis (N-picolyl) benzimidazoliumyl) methane hexafluorophosphate …
Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions
DK Tosh, F Deflorian, K Phan, ZG Gao… - Journal of medicinal …, 2012 - ACS Publications
(N)-Methanocarba adenosine 5′-methyluronamides containing known A3 AR (adenosine
receptor)-enhancing modifications, ie, 2-(arylethynyl) adenine and N 6-methyl or N 6-(3 …
receptor)-enhancing modifications, ie, 2-(arylethynyl) adenine and N 6-methyl or N 6-(3 …
Frontal affinity chromatography− Mass Spectrometry useful for characterization of new ligands for GPR17 receptor
The application of frontal affinity chromatography-mass spectrometry (FAC-MS), along with
molecular modeling studies, to the screening of potential drug candidates toward the …
molecular modeling studies, to the screening of potential drug candidates toward the …
2-Triazole-Substituted Adenosines: A New Class of Selective A3 Adenosine Receptor Agonists, Partial Agonists, and Antagonists
L Cosyn, KK Palaniappan, SK Kim… - Journal of medicinal …, 2006 - ACS Publications
“Click chemistry” was explored to synthesize two series of 2-(1, 2, 3-triazolyl) adenosine
derivatives (1− 14). Binding affinity at the human A1, A2A, and A3ARs (adenosine receptors) …
derivatives (1− 14). Binding affinity at the human A1, A2A, and A3ARs (adenosine receptors) …
First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences
DK Tosh, CL Fisher, V Salmaso, TC Wan… - ACS Pharmacology & …, 2023 - ACS Publications
(N)-Methanocarba adenosine derivatives (A3 adenosine receptor (AR) agonists containing
bicyclo [3.1. 0] hexane replacing furanose) were chain-extended at N 6 and C2 positions …
bicyclo [3.1. 0] hexane replacing furanose) were chain-extended at N 6 and C2 positions …
Ruthenium‐Catalyzed Oxidative Annulation of 6‐Anilinopurines with Alkynes via CH Activation: Synthesis of Indole‐Substituted Purines/Purine Nucleosides
S Allu, KC Kumara Swamy - Advanced Synthesis & Catalysis, 2015 - Wiley Online Library
Indole‐substituted purine nucleobases have been synthesized by Ru‐catalyzed oxidative
annulation of 6‐anilinopurines with internal alkynes that involves C H activation …
annulation of 6‐anilinopurines with internal alkynes that involves C H activation …
Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering
KA Jacobson, AM Klutz, DK Tosh, AA Ivanov… - Adenosine Receptors in …, 2009 - Springer
Abstract A 3 adenosine receptor (A 3 AR) ligands have been modified to optimize their
interaction with the A 3 AR. Most of these modifications have been made to the N 6 and C2 …
interaction with the A 3 AR. Most of these modifications have been made to the N 6 and C2 …
Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications
PG Baraldi, D Preti, PA Borea… - Journal of medicinal …, 2012 - ACS Publications
The purine nucleoside adenosine is identified as a ubiquitous molecule regulator of different
tissues and cell functions. 1 Adenosine is generated in the extracellular space by the …
tissues and cell functions. 1 Adenosine is generated in the extracellular space by the …