Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Background: The tuberculin skin test (TST) has low specificity. QuantiFERON-TB Gold (QFT-
G) and T-SPOT. TB are based on interferon (IFN)-γ responses to Mycobacterium …

Our understanding of the infection risks presented by tumour necrosis factor (TNF)
antagonists has continued to evolve in the 10 years since these drugs were first introduced …

Previously we have shown that Ag85B-ESAT-6 is a highly efficient vaccine against
tuberculosis. However, because the ESAT-6 Ag is also an extremely valuable diagnostic …

Background Previously we have shown that Ag85B-TB10. 4 is a highly efficient vaccine
against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic …

We evaluated the T-SPOT. TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for
diagnosing Mycobacterium tuberculosis infection. T-SPOT. TB was more sensitive than QFN …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects~ 8
million annually culminating in~ 2 million deaths. Moreover, about one third of the …

OBJECTIVE: Interferon-gamma release assays (IGRA) are now available alternatives to
tuberculin skin testing (TST) for detection of latent tuberculosis infection (LTBI). We …

Performance of interferon-γ (IFN-γ) release assays still needs to be improved. The data on
the performance of QuantiFERON-TB Gold Plus (QFT-Plus), a new-generation of QFT assay …