Gram-negative bacteria can resist antibiotics by changing the permeability via their outer
membrane. These bacteria have a complex cell envelope that incorporates an outer …

In Enterobacteriaceae, susceptibility to cephalosporins and carbapenems is often
associated with membrane and enzymatic barrier resistance. For about 20 years, a large …

β barrels are ubiquitous proteins in the outer membranes of mitochondria, chloroplasts, and
Gram-negative bacteria. These transmembrane proteins (TMPs) execute a wide variety of …

Efficient permeation into Gram-negative bacterial cells is a much-desired property in the
design of antibacterial agents. The goal is to arrive at one or more chemical modifications of …

Ion channels exhibit gating behavior, fluctuating between open and closed states, with the
transmembrane voltage serving as one of the essential regulators of this process. Voltage …

The sophisticated envelope of Gram-negative bacteria modulates the uptake of small
molecules in a side-chain-sensitive manner. Despite intensive theoretical and experimental …

The recombinant expression, isolation and characterization of pore-forming proteins is one
of the most commonly used strategies for understanding the permeability properties of the …

Recent advances in molecular dynamics (MD) simulations have led to rapid improvement in
our understanding of the molecular details of the outer membranes (OMs) of Gram-negative …

Experimental studies on the translocation and accumulation of antibiotics in Gram-negative
bacteria have revealed details of the properties that allow efficient permeation through …

We investigated, by using all‐atom molecular dynamics simulations, the effect of the outer
membrane of Gram‐negative bacteria, composed in the outer leaflet by polar/charged …