Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

A major rate-limiting step in developing more effective immunotherapies for GBM is our
inadequate understanding of the cellular complexity and the molecular heterogeneity of …

The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …

Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

Abstract β-Elemene is a sesquiterpene compound extracted from the herb Curcuma
Rhizoma and is used in traditional Chinese medicine (TCM) to treat several types of cancer …

Lung metastasis is the leading cause of breast cancer-related death. The tumor
microenvironment contributes to the metastatic colonization of tumor cells in the lungs …

Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how
these cancer cells interact with each other is still largely unknown. Exosomes released by …

S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of
vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis …

Understanding the cellular composition of the tumor microenvironment and the interactions
of the cells is essential to the development of successful immunotherapies in cancer. We …