Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …

Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans
and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) …