There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …

Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

Intracellular malaria parasites require lipids for growth and replication. They possess a
prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid …

Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in
the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) …

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated
sporozoites (RAS) remain the" gold standard" for sterilizing protection against Plasmodium …

For 50 years since their discovery, the malaria parasite liver stages (LS) have been difficult
to analyze, impeding their utilization as a critical target for antiinfection vaccines and drugs …

Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce
sterilizing protection against malaria in both humans and rodents. Importantly, these “whole …