Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …

Soluble expression of recombinant proteins in E. coli is often done by translocation of the
product across the inner membrane (IM) into the periplasm, where it is retained by the outer …

Real‐time estimation of physiological properties of the cell during recombinant protein
production would ensure enhanced process monitoring. In this study, we explored the …

Lack of appropriate process models, reliable online sensors, and process variability in
bioprocess systems are poising challenges in real-time monitoring and control of critical …

Specific growth rate (SGR) is a key process parameter that affects cell growth and
recombinant protein expression in Escherichia coli (E. coli). Post induction, cell metabolism …

Microbial biomass concentration is a key bioprocess parameter, estimated using various
labor, operator and process cross-sensitive techniques, analyzed in a broad context and …

During the epoch of sustainable development, leveraging cellular systems for production of
diverse chemicals via fermentation has garnered attention. Industrial fermentation …

Accurate and reliable estimation of specific growth rate (μ) in real-time is pivotal for reliable
process monitoring of a bioprocess and subsequent implementation of advanced control …

Real‐time monitoring of glycoengineered Pichia pastoris by employing process analytical
technology (PAT) tools is vital for gaining deeper insights into the therapeutic protein …